Dr White

Why some girls are easy to fat stomach? Scientists have made a new discovery

By Dr White

 


An article published Feb. 16 in the subjournal Nature found that some women are more likely to put on a small belly, which is actually influenced by genes.


New study reveals fat belly gene

The research team first compared the genomes of hundreds of people to identify genes associated with obesity and high Waist-to-Hip Ratio. The Waist-to-Hip Ratio is a good indicator of abdominal fat, and the higher the ratio the less healthy it is.

After genetic analysis, they targeted genes associated with 91 genes that help regulate fat distribution primarily in women.

One gene in particular caught the researchers' attention as having the strongest association with waist-hip height in women ----SNX10

Although men also express this gene, it does not affect the waist-to-hip ratio in men.

After various verifications, it is true that this gene is the biggest suspect in causing abdominal obesity in women!

First, this gene has the ability to control the growth and deposition of fat cells. When female mice with the SNX10 gene are fed a high-fat diet, they get fat; when the gene is knocked out and the females are fed the same thing, they don't get fat. But male mice fed a high-fat diet would get fat with or without the gene.


After initial validation in mice, the researchers searched the UK Biobank, a large human database containing more than 700,000 genomes and body information.

It was found that SNX10 was associated not only with a higher waist-to-hip ratio in women, but also with higher cholesterol and triglyceride levels.

Fat stomach is bad, but it's not your fault

It is now widely accepted in the medical community that waist circumference and Waist-to-Hip Ratio are better measures of a person's health than weight or BMI. Fat deposition in the abdomen is associated with increased insulin resistance and inflammation, and predicts a higher risk of cardiovascular disease, kidney failure, and stroke.

For our adults, a  Waist-to-Hip Ratio of more than 0.8 for women and 0.9 for men is considered centrally obese. On this basis, every 0.1 increase in waist-to-hip ratio increases the risk of all-cause mortality by 20%.

Men have actually been observed to be more likely to be centrally obese (e.g., beer belly) than women, but women can be more bothered by it.

One survey found that women are more likely than men to feel shame about belly fat, regardless of weight. This is because messages from outside tell them that a small belly means "unattractiveness, self-indulgence, or weakness of will," which brings about self-depreciation.

In reality, however, fat accumulation can be influenced by many factors such as genetics, behavior, and environment. Having a prominent tummy does not mean that you are doing anything wrong compared to others, it may just be that you have been assigned an ancestral SNX10 gene.

From a health perspective, we do need to put in some extra effort to reduce belly fat, but don't be self-denying.

You've done a great job of fighting the will of your genes! 



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